Potential risk factors included the total number of instances of vaginal intercourse (continuous variable), the number of new partners (0, 1, or >1), the frequency of condom use by partners (<5 percent, 5 to 49 percent, 50 to 99 percent, or 100 percent), the partner's circumcision status (circumcised, uncircumcised, or unknown), and the partner's number of previous partners (0, ?1, or unknown). The frequency of condom use was calculated by dividing the number of condoms used for vaginal intercourse by the number of instances of vaginal intercourse during the eight-month study period. If multiple new partners were reported during an eight-month period, the circumcision status and previous number of partners were summarized ( Table 1 ). The percentage of days that lacked diary entries was calculated to assess potential confounding created by missing data. The effect of the frequency of condom use was evaluated by multivariate analysis with the inclusion of other variables that were found to be significant (P<0.10) in univariate analyses. Similar analyses were performed to evaluate risk factors for high-risk types of HPV (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68, 73, and 82), 20,21 low-risk types (6, 11, 40, 42, 54, 55, 57, 61, 62, 64, 69, 70, 71, 72, 81, 83, 84, and CP6108), 20,21 and types 6, 11, 16, and 18 (which are included in quadrivalent vaccine trials 22 ). To evaluate whether the effect of condom use on the risk of HPV infection differed according to the location in the genital tract, similar analyses were performed to examine risk factors for incident cervical and vulvovaginal infections.

From inside the subanalyses, sufferers whoever lovers put condoms 100 percent of the time had been divided into a few kinds on the basis of its solutions to the question “Performed your lover’s knob ever before reach the opening of your genitals in the place of an excellent condom?” In the event that sufferers always replied “no” per work out-of vaginal sex for the seven-week months, they certainly were coded due to the fact which have got “zero genital get in touch with as opposed to a beneficial condom.” Analyses were performed because the discussed over, with four kinds of this new frequency out-of condom explore (completely without the genital contact instead of good condom, 100 % which includes or an unidentified regularity out of genital contact versus a condom, and you may around three communities lower than 100 percent, just like the described over).

Furthermore, Cox proportional-dangers patterns were used to decide risk circumstances on identification away from experience cervical squamous intraepithelial lesions in 7 months in advance of a given Pap test (on such basis as a past observation that the majority of lesions can be found appropriate event illness 23 ). A great https://datingranking.net/threesome-sites/ 51-go out lag prior to each visit is actually incorporated since 51 weeks try the new smallest noticed period amongst the time a woman very first got intercourse and also the big date out of detection off a case lesion in this study. Studies to have such as for example sufferers was in fact censored adopting the earliest recognition of an incident lesion.

Abilities

The latest suggest (±SD) age of the newest 82 victims in the enrollment try 19.3±0.eight many years. The fresh subjects done 709 visits. The latest mean follow-upwards time was 33.9±11.8 days, the brand new imply amount of check outs for every single woman is actually 8.6±dos.9, as well as the median time taken between visits try cuatro.1 days. Log research have been ninety.eight percent complete, and condom research were registered to your 99.step 3 per cent regarding days that sex try said.

Desk 2

The latest a dozen-month cumulative incidence from an initial HPV problems immediately following first gender try 37.2 per cent (95 percent depend on interval, twenty seven.2 so you’re able to 44.4 percent). All in all, 126 incident sort of-certain infection was recognized in 40 females after they earliest had gender ( Dining table dos ). Incident bacterial infections were recognized in three girls in advance of they stated that have intercourse for the first time, plus one to self-confident having HPV types of 51, one to having HPV types of 6, plus one to own HPV products 40, 61, and you can 66. The brand new twenty-four-few days cumulative occurrence off cervical squamous intraepithelial lesions try fifteen.0 percent (95 percent count on interval, 8.3 in order to twenty-six.dos percent).